Embryos with DNA from three people develop normally in first safety study

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Embryos with DNA from three people develop normally in first safety study
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Researchers in China show that a technique used to replace diseased mitochondria does not affect early development.

Researchers in China have tested the safety of a technique to replace defective mitochondria in early humans embryos.When the first baby to be conceived using a technique that mixes genetic material from three people, in 2016, scientists worried that the procedure had not been studied to show it was safe.

As part of the study, the team compared dozens of human embryos that underwent spindle transfer with a control group of embryos. Both sets of embryos were allowed to develop for up to one week after fertilization. The researchers found that cells from a five-day old ‘blastocyst’ in both groups had almost identical levels of gene expression and transcription, suggesting that spindle transfer does not seem to affect early embryonic development.

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Nature /  🏆 64. in US

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