Eliminating only milk not only reduced symptoms but also improved quality of life for patients with eosinophilic esophagitis. MedTwitter
Previous studies have found that eliminating six common foods that trigger esophageal injury — milk, eggs, wheat, soy, fish, and nuts — can substantially reduce EoE symptoms. The 6FED has become a common approach to managing the disease.
Between 2016 and 2019, 67 participants were assigned to the 1FED group, which eliminated only animal milk from the diet, and 62 participants were assigned to the 6FED group, which eliminated milk, eggs, wheat, soy, fish/shellfish, and peanuts/tree nuts. After following the diet for 6 weeks, participants underwent an upper endoscopy exam and esophageal tissue biopsy.
There were also no significant differences between the groups at stricter thresholds for partial remission, defined as peak counts of ≤10 eos/hpf and ≤6 eos/hpf. The rate of complete remission favored 6FED, at 19%, vs 6% among 1FED. "We examined a series of validated endpoints that have not previously been examined in diet trials," Rothenberg said."We are surprised to see that one food was equally effective as six foods."Rothenberg and colleagues are continuing their research into EoE and food-elimination diets, with a strong focus on furthering diet therapy. In particular, the research team wants to understand how to potentially add milk — and other foods — back to the diet, he said.
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