Researchers investigate chromatin conformational and epigenomic reorganization during the development of the prefrontal cortex and hippocampus.
By Tarun Sai LomteReviewed by Benedette Cuffari, M.Sc.Oct 14 2024 New insights into brain development: study maps chromatin changes linked to psychiatric disorders in prenatal and infant stages.
Recent studies have reported chromatin remodeling in early postnatal development. Nevertheless, the trajectories of DNA methylation and chromatin conformational changes in prenatal brain tissues have not been characterized at single-cell resolution. Chromatin interactions and validation Single-cell 3C profiles were subsequently clustered by the distance distribution between interacting loci. To this end, neuronal cell types were strongly enriched in clusters dominated by short-range interactions, whereas non-neural and glial cells were enriched in clusters dominated by long-range interactions.
RNA MERFISH was performed on the same tissue sections. In neuronal cell types, genomic regions separated by short distances of up to five Mb had a compact spatial distance, thus indicating high interaction frequency. Neuropsychiatric disorder heritability Over 2.5 million differentially methylated regions were identified across developmental stages and cell types. Transcription factor -binding motif analysis revealed that the sequential action of lineage-specific and activity-dependent TFs shapes the regulatory landscape of inhibitory and excitatory neurons.
Bipolar Disorder Cell Chromatin Chromosome Cortex Cytosine DNA DNA Methylation Frequency Genetic Genomic Guanine Hippocampus Neurons Pregnancy Prenatal RNA Schizophrenia
Deutschland Neuesten Nachrichten, Deutschland Schlagzeilen
Similar News:Sie können auch ähnliche Nachrichten wie diese lesen, die wir aus anderen Nachrichtenquellen gesammelt haben.
Researchers find cord blood cells can build a better human immune system into miceImmunity plays a central role in the fight against cancer. Many of the current immunotherapies aim at helping the patient's immune system to better recognize cancer cells—by using engineered antibodies—or by simply providing it with new cells, pre-equipped to search and destroy cancer.
Weiterlesen »
Researchers suggest motor delay and low muscle tone may indicate genetic disordersIn a new study, UCLA Health researchers have found that motor delay and low muscle tone were common signs of an underlying genetic diagnosis in children with neurodevelopment disorders.
Weiterlesen »
Researchers clarify role of VGLL3 in DNA double-strand break repair and chemotherapyA research group led by Prof. Guo Caixia from the Beijing Institute of Genomics of the Chinese Academy of Sciences (CAS) and Tang Tie-Shan from the Institute of Zoology of CAS have discovered that VGLL3 modulates chemosensitivity through promoting DNA double-strand break repair. The study was published in Science Advances.
Weiterlesen »
Researchers develop precision surgical technique for lymph node removal in endometrial cancerA joint research team has announced that it is possible to detect and precisely remove metastatic lymph nodes during endometrial cancer surgery using neo-mannosyl human serum albumin-indocyanine green (MSA-ICG) and a laparoscopic fluorescence imaging system.
Weiterlesen »
Drexel University Researchers Share Tips for Combatting Caffeine DependenceA recent study from Drexel University highlights the increasing prevalence of caffeine dependence and provides practical advice on how to manage it. The article explores the symptoms of caffeine withdrawal, risk factors, and expert-recommended strategies for gradually reducing caffeine intake.
Weiterlesen »
Researchers develop innovative mouse model for studying cancer immunotherapyImmunity plays a central role in the fight against cancer. Many of the current immunotherapies aim at helping the patient's immune system to better recognize cancer cells - by using engineered antibodies - or by simply providing it with new cells, pre-equipped to search and destroy cancer.
Weiterlesen »