Long-term lipid lowering with evolocumab further reduces CV events, including CV death by 23%, without a safety signal, according to results from the FOURIEROLE study. ESCCongress
Pivotal statin trials have median follow-up times of 4-5 years and demonstrated both a lag effect, meaning clinical benefit grew over time, and a legacy effect, where clinical benefit persisted in extended follow-up after the parent study, O'Donoghue observed.
Their mean age was 62 years, three fourths were men, a third had diabetes. Three fourths were on a high-intensity statin at the time of enrollment in FOURIER, and median LDL-cholesterol at randomization was 91 mg/dL . Their risk of CV death, MI, or stroke was 20% lower , and, as noted previously, 23% lower for CV death.
Although early studies raised concerns that very low LDL cholesterol may be associated with an increased risk of hemorrhagic stroke and neurocognitive effects, the frequency of adverse events did not increase over time with evolocumab exposure.
Deutschland Neuesten Nachrichten, Deutschland Schlagzeilen
Similar News:Sie können auch ähnliche Nachrichten wie diese lesen, die wir aus anderen Nachrichtenquellen gesammelt haben.
Oakland police chief decries 'incomprehensible' gun violence; 6 homicides in 4 daysOakland Police Chief LeRonne Armstrong on Monday held a press conference to offer details on the latest round of deadly street violence in his city that claimed six lives.
Weiterlesen »
Columbus deputy police chief suing city now potentially faces firing for missed drug testColumbus police Deputy Chief Jennifer Knight missed a drug test because of work obligations in November. She's now facing potential discipline.
Weiterlesen »
Civil rights attorney calls for investigation, charges for former Lexington police chiefAttorney Malik Shabazz announced Monday outside the Lexington Police Department that Washington, D.C.-based legal group Black Lawyers for Justice plans to review the police department and how it operated under former police chief Sam Dobbins.
Weiterlesen »
NASA chief reflects on Monday's scrubbed rocket launch | Digital TrendsNASA chief BillNelson has been speaking about the space agency’s decision to call off the maiden launch of its next-generation rocket on Monday.
Weiterlesen »
YouTube’s Chief Business Officer Robert Kyncl to Step Down in OctoberOn Oct. 3, YouTube’s chief business officer, Robert Kyncl, is stepping down and will be succeeded by Mary Ellen Coe, currently the president of global customer solutions at Google
Weiterlesen »