The therapeutic potential of oleuropein (OLE) and hydroxytyrosol (HT) from olive oil.
By Vijay Kumar MalesuMar 15 2024Reviewed by Lily Ramsey, LLM In a recent review published in the Nutrients, a group of authors explored the therapeutic potential of oleuropein and hydroxytyrosol from olive oil as novel antioxidants in the treatment of neuroblastoma , addressing challenges such as recurrence and drug resistance.
Further, in vivo studies and clinical trials are essential to confirm their therapeutic efficacy and safety in NB cases. The role of oxidative stress Oxidative stress, characterized by an imbalance between reactive oxygen species and antioxidant defenses, catalyzes cellular damage. Future research is essential to fully tap into the therapeutic potential of antioxidants in managing NB.
HT: An antioxidant powerhouse HT emerges from the enzymatic breakdown of OLE and other glycosides, known for its robust anti-inflammatory, antiatherogenic, and antithrombotic properties. Interestingly, at higher doses, OLE and HT exhibit pro-oxidant activity, which may contribute to their anticancer effects by inducing oxidative stress in cancer cells.
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