Studies showed the Daxxify drug can temporarily improve moderate to severe frown lines in adults for a median duration of about six months, according to the company. FOX13
for therapeutic use in 1989 and was later studied and rebranded for the treatment of moderate to severe frown lines. In 2002, the FDA approved it as a temporary cosmetic treatment for wrinkles — the first of its kind. The agency requested the AbbVie product be marketed as "BOTOX Cosmetic" to distinguish cosmetic from therapeutic uses, according to a product history.
Like Botox, Daxxify is an acetylcholine release inhibitor and neuromuscular blocking agent. This means blocking certain chemical signals from nerves, mostly signals that cause muscles to contract, according toThe most common use of Botox, and now Daxxify, is to temporarily relax the facial muscles that cause wrinkles. Botox injections are also used to treat conditions such as neck spasms, excessive sweating, an overactive bladder, and lazy eye, the Mayo Clinic adds.
Daxxify was found to be "generally safe and well tolerated" with no serious treatment-related adverse events reported in during the clinical trials, Revance said. The most common treatment-related adverse events in the pivotal trials were headache followed by eyelid ptosis or a drooping eyelid and facial paresis, including facial asymmetry , the company said.
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