A 500m (1,640ft) cordon has been put in place and people have been warned to avoid the area.
Firefighters have shut a number of roads in Northampton town centre as they battle a "large-scale" fire at a disused bar.
Road users have been warned to avoid the area while Angel Street, Derngate and Victoria Promenade are also closed. There has been no access via St Peter's Way, Gold Street, Abington Street or The Drapery while the cordon is in place.Northamptonshire Fire and Rescue Service was called to Bridge Street at about 05:30 BST
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