A Case Report in BMCWomensHealth discusses the case of a yolk sac tumor accompanied by subsequent endometrial cancer associated with Li-Fraumeni syndrome and family history of cancer. It highlights the need of screening for malignancy and family history.
Imaging results of endometrial cancer. Magnetic resonance imaging shows that the endometrium is thickened, with a thickness of about 1.6 cm , and the signal and enhancement are not uniform . Positron emission tomography/computed tomography shows increased fluorodeoxyglucose metabolism in the uterine cavity, consistent with endometrial cancer changes , PR , P53 , Ki-67 , cytokeratin 8/18 , MLH1, PMS2, MSH2, MSH6 and NapsinA negative .
]. There is little research evidence on the use of bevacizumab in EC while a clinical trial suggested that IHC for p53 alone or when integrated with sequencing for]. In light of the patient’s history of two gynecological malignancies and her family history of cancer, we conducted nextgeneration sequencing of formalin-fixed paraffin-embedded EC tissue.
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