Ingestible capsule to address GItract diseases UofMaryland
A capsule with a white paper indicator packaged inside was coated with the FRRB . Then, the capsule was incubated in an acid bath . It was then translated across the tissue phantom in neutral solution .Paper strips protected/released by the capsule after four conditions: Blank/no incubation; 30 min of acid incubation and exposure in neutral solution on the GI simulator. Negative control/acid solution. Both acid and neutral solutions.
It was then dip coated utilizing a wrapping film masking technique to individually coat each opening with a different number of FL30 layers . The ports were coated with 1, 2, and 3 layers of FL30 to induce the sequential exposure of the three cavities. This design could be used to release payloads at different positions in the GI tract with a single capsule.
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