A World Health Organization advisory panel says more research is needed to explain how SARSCoV2 made it into people to spark the pandemic.
in China and Laos have about 96% genetic similarity to SARS-CoV-2—a significant evolutionary distance, which leads many scientists to suspect an “intermediate host” harbored the virus before it reached people. SAGO’s 46-page report spotlights the same possibility Worobey’s work supported: that the virus spilled over from this host at the Huanan Seafood Market in Wuhan, which sold many mammals as well as seafood and had the first cluster of cases.
One of the few pieces of fresh information in the report came from Chinese researchers, who responded to a request from SAGO and provided new data on blood samples taken from 40,000 people in Wuhan before the first COVID-19 cases surfaced in December 2019. Although 200 tested positive for antibodies to SARS-CoV-2, those antibodies could not neutralize the virus in a confirmatory test, suggesting these were false positives.
The three SAGO members who challenged the decision to include the lab-leak possibility contended in a footnote that “there is no new scientific evidence” to question the joint commission’s earlier conclusion that this was “extremely unlikely.” “I want to have something much more solid than just a hypothesis,” says Carlos Morel, a parasitologist at the Oswaldo Cruz Foundation in Rio de Janeiro, one of the three dissenters.
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