The largest cohort of its kind reveals notable genomic features among young premenopausal women with HR-positive early breastcancer and could represent key targets for therapy.
have notable genomic features that may help explain their historically poor outcomes and offer clues about molecular targets for future trials.
Charis Eng, MD, PhD, of the Cleveland Clinic Genomic Medicine Institute, Ohio, noted that the findings are promising but need further validation. Although previous studies have identified key gene expression signatures linked to worse outcomes in younger patients with breast cancer, there are limited data on this younger patient population, especially by breast cancer subtype. Given that breast cancer treatment strategies are often similar across age groups, such evidence gaps could represent missed opportunities for developing more targeted treatment strategies for this high-risk population of young women.
Younger women also had significantly higher features suggestive of homologous recombination deficiency , and a higher proportion of PIK3CA mutations with concurrent copy number-amplifications , all considered to be poor prognostic features. Compared with women without those features, women with poor prognostic features had a lower 8-year distant recurrence-free interval of 84% vs 94% , and worse 8-year overall survival of 88% vs 96%, respectively . Notably, younger women under age 40 had the poorest outcomes, with an 8-year distant recurrence-free interval rate of 74% vs 85% in older women, and an 8-year overall survival of 80% vs 93%, respectively.
Deutschland Neuesten Nachrichten, Deutschland Schlagzeilen
Similar News:Sie können auch ähnliche Nachrichten wie diese lesen, die wir aus anderen Nachrichtenquellen gesammelt haben.
Robot reveals clues behind what's eating away at Antarctica's 'doomsday glacier'Scientists got their first close-up look at what is eating away part of Antarctica's Thwaites ice shelf — nicknamed the 'doomsday glacier' because of how much sea levels rise if it all melts — and it's both good and bad news.
Weiterlesen »
Chelsea's new signings starting to settle despite poor results - HavertzChelsea forward Kai Havertz said he was encouraged by the way the club's new signings are gelling with the team despite the side recording only one win in 2023.
Weiterlesen »
Is the Life of a Poor Person Worth Less Than a Rich Human?Why on earth are people's lives being valued differently depending on the country they live in?
Weiterlesen »
Analysis: U.S. food benefits for poor to shrink as pandemic provisions endLow-income Americans will soon receive less in food assistance or completely lose their eligibility for the benefits, as the federal government ends policies adopted at the beginning of the COVID-19 pandemic that kept millions from going hungry at a time of lockdowns and rising unemployment.
Weiterlesen »
Philadelphia's Little Sisters of the Poor show true meaning of caregivingAs we look ahead to National Caregivers Day, we thank the Little Sisters of the Poor for treating the elderly like family in Philadelphia.
Weiterlesen »