A Key Step Forward One in nine adults worldwide has some kind of kidney disease, and kidney failure is becoming more common everywhere. Growing functional kidney tissue in a lab could accelerate kidney disease treatments and restore kidney function. In humans, the kidney forms naturally as a conseq
Human kidney ureteric bud organoids derived from stem cells and stained for different proteins. Credit: Bonventre Lab/Brigham and Women’s HospitalOne in nine adults worldwide has some kind of kidney disease, and kidney failure is becoming more common everywhere. Growing functional kidney tissue in a lab could accelerate kidney disease treatments and restore kidney function. In humans, the kidney forms naturally as a consequence of two building blocks: metanephric mesenchyme and ureteric bud.
Seven years ago, researchers in Dr. Joseph Bonventre’s laboratory discovered how to create the first building block, known as metanephric mesenchyme, from human stem cells. Dr. Bonventre is the Chief of the Renal Unit and Founding Chief of the Engineering in Medicine Division at theThe same team has recently created a very efficient method for producing the second building block , which grows into the adult kidney collecting system.
“We have developed a highly efficient way to generate a key component of kidney tissue responsible for maintaining many blood chemistries and critically important for development of the kidney. In addition, we have created, for the first time, human kidney cells that can be used to advance new drugs, aid in the investigation of inherited and acquired disorders, and improve our understanding of how the kidney develops and control metabolic balance in the body,” said Bonventre.
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