Emerging artists tell BBC Newsbeat how they're shaping the genre for the future.
Jordan Adetunji draws inspiration from his Nigerian heritage and Belfast upbringing for a fresh take on hip-hopHip-hop is 50 years old, and over the last few decades the genre's created a long list of icons who've changed the face of music.
Since then, experimentation has been a trademark of hip-hop, with artists keeping one foot in the past as they create innovative, exciting new sounds. Spin-off sub-genres like drill and grime, and regional scenes in Europe, South America and Asia have kept the sounds fresh and made the genre a global powerhouse.
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On the 50 Year Anniversary of Hip-hop, The UK remembers TYOn the 50 Year Anniversary of Hip-hop, The UK remembers TY Chijioke A Brixton mural for the fallen UK Hip-hop artist has been regenerated in a fitting UK tribute to mark the 50 Year Anniversary of Hip-hop. HipHop50 TyChijioke
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Jones: Hip-hop turns 50, shapes dreams and serves as a bridge to sports and musicShaquille O’Neal was a platinum-selling rapper. Some didn’t understand why Ken Griffey Jr. wore his hat backward during batting practice. With hip-hop turning 50 years old Friday, mr_jasonjones explores the relationship between the genre and sports.
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Hip hop celebrates its 50th birthdayFifty years ago today, a birthday party in the Bronx started what’s now the most commercially successful music genre in the world. AyshahTull reports as hip hop turns 50.
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Hip-hop’s 50th anniversary shines a light on its New York City birthFrom humble beginnings on Bronx streets to billionaires and bling
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Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration - Journal of NeuroinflammationMicroglia are the resident innate immune cells in the brain with a major role in orchestrating immune responses. They also provide a frontline of host defense in the central nervous system (CNS) through their active phagocytic capability. Being a professional phagocyte, microglia participate in phagocytic and autophagic clearance of cellular waste and debris as well as toxic protein aggregates, which relies on optimal lysosomal acidification and function. Defective microglial lysosomal acidification leads to impaired phagocytic and autophagic functions which result in the perpetuation of neuroinflammation and progression of neurodegeneration. Reacidification of impaired lysosomes in microglia has been shown to reverse neurodegenerative pathology in Alzheimer’s disease. In this review, we summarize key factors and mechanisms contributing to lysosomal acidification impairment and the associated phagocytic and autophagic dysfunction in microglia, and how these defects contribute to neuroinflammation and neurodegeneration. We further discuss techniques to monitor lysosomal pH and therapeutic agents that can reacidify impaired lysosomes in microglia under disease conditions. Finally, we propose future directions to investigate the role of microglial lysosomal acidification in lysosome–mitochondria crosstalk and in neuron–glia interaction for more comprehensive understanding of its broader CNS physiological and pathological implications.
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