Steve Powis said the health service was enduring “extreme pressure this winter”.
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NHS discharges patients into hotels to ease bed blocking and A&E crisisThree NHS areas in the south west of England booked out hotels run by private health providers for patients with non-critical needs due to a shortage of social care provision
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NHS Wales: Man carries grandad into hospital amid ambulance shortageThere were no ambulances available to respond after an 83-year-old man collapsed.
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NHS Providers calls for end to 'temporary fixes' to hospital bed-blocking crisis🔴 A health chief has called for an end to “temporary fixes” to the NHS crisis after theipaper revealed at least three hospital groups were opening “care hotels” to help ease the pressure on beds
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Glasgow hospital patients face 12-hour wait in A&E ahead of ChristmasOver 500 people had to wait over 12 hours to be seen in Glasgow's accident and emergency departments in the week before Christmas as services faced increased pressure.
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St George's Hospital declares critical incident amid pressureIn a letter to staff, the hospital says 'urgent action' is required to discharge patients.
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Interactive Effects of Molecular, Therapeutic, and Patient Factors on Outcome of Diffuse Low-Grade Glioma | Journal of Clinical OncologyPURPOSE In patients with diffuse low-grade glioma (LGG), the extent of surgical tumor resection (EOR) has a controversial role, in part because a randomized clinical trial with different levels of EOR is not feasible. METHODS In a 20-year retrospective cohort of 392 patients with IDH-mutant grade 2 glioma, we analyzed the combined effects of volumetric EOR and molecular and clinical factors on overall survival (OS) and progression-free survival by recursive partitioning analysis. The OS results were validated in two external cohorts (n=365). Propensity score analysis of the combined cohorts (n=757) was used to mimic a randomized clinical trial with varying levels of EOR. RESULTS Recursive partitioning analysis identified three survival risk groups. Median OS was shortest in two subsets of patients with astrocytoma: those with postoperative tumor volume (TV) | 4.6 mL and those with preoperative TV | 43.1 mL and postoperative TV ≤ 4.6 mL. Intermediate OS was seen in patients with astrocytoma who had chemotherapy with preoperative TV ≤ 43.1 mL and postoperative TV ≤ 4.6 mL in addition to oligodendroglioma patients with either preoperative TV | 43.1 mL and residual TV ≤ 4.6 mL or postoperative residual volume | 4.6 mL. Longest OS was seen in astrocytoma patients with preoperative TV ≤ 43.1 mL and postoperative TV ≤ 4.6 mL who received no chemotherapy and oligodendroglioma patients with preoperative TV ≤ 43.1 mL and postoperative TV ≤ 4.6 mL. EOR ≥ 75% improved survival outcomes, as shown by propensity score analysis. CONCLUSION Across both subtypes of LGG, EOR beginning at 75% improves OS while beginning at 80% improves progression-free survival. Nonetheless, maximal resection with preservation of neurological function remains the treatment goal. Our findings have implications for surgical strategies for LGGs, particularly oligodendroglioma.
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