A team of researchers has shown that a single, small strand of microRNA, or miRNA, known as let-7, governs the ability of T-cells to recognize and remember tumor cells. This cellular memory is the basis for how vaccines work. Boosting cellular memory to recognize tumors could help improve cancer therapies. The research suggests a new strategy for the next generation of cancer-fighting immunotherapies.
A team of researchers at the University of Massachusetts Amherst has shown that a single, small strand of microRNA, or miRNA, known as let-7, governs the ability of T-cells to recognize and remember tumor cells. This cellular memory is the basis for how vaccines work. Boosting cellular memory to recognize tumors could help improve cancer therapies. The research, published recently in, suggests a new strategy for the next generation of cancer-fighting immunotherapies.
"But," says Pobezinsky,"somehow a few survive, transform into memory cells and form an elite task force called the 'memory pool' -- they remember what that particular antigen looked like, so that they can be on the lookout for the next time it invades the body." "What we've discovered," says Pobezinsky,"is that a tiny piece of miRNA, let-7, which has been handed down the evolutionary tree since the dawn of animal life, is highly expressed in memory cells, and that the more let-7 a cell has, the less chance that it will be tricked by cancerous tumor cells, and the greater chance it has of turning into a memory cell.
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