How COVID-19 variants emerge — and how we can prepare for the next one

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How COVID-19 variants emerge — and how we can prepare for the next one
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It\u0027s wishful thinking to imagine SARS\u002DCoV\u002D2\u0027s evolution is somehow done, \u0027because we are so culturally and politically, and economically done with it.\u0027

SARS-CoV-2 enters the body through the respiratory system. It finds a healthy target cell that has receptors on its surface, in this case, the ACE2 receptor, that it uses to dock onto, and slip inside the cell. Once inside, the virus starts replicating, copying its genetic code over and over again.

“We talk a lot about the spike, but there are 23 other proteins in that virus and each have a role in how virulent the variants are, how transmissible they are, how stable they are,” University of Ottawa virologist Marc-André Langlois said during a recent panel discussion hosted by Canada’s COVID-19 Immunity Task Force and featuring experts from the Coronavirus Variants Rapid Response Network, or CoVaRR-Net.

It’s wishful thinking to imagine SARS-CoV-2 is running out of steam, that its evolution is somehow done, “because we are so culturally and politically, and economically done with it,” COVID-19 modeller Caroline Colijn, of Simon Fraser University, said in an earlier interview. “I think evolution will continue to act. The way to stop evolution from giving us more variants is to reduce the size of the virus populations, and that’s infections. That’s not just hospitalizations.

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