What Is an Intradermal Injection, the New Way the Monkeypox Vaccine Is Being Given?
: Subcutaneous injections are given at a 45-degree angle, usually in the thigh or upper-outer triceps area for people over 12 months. The MMR and varicella vaccines are subcutaneous.The FDA is recommending that monkeypox vaccines be given intradermally to try to stretch out the current vaccine supply. Going this route will allow healthcare providers to give five people the vaccine for every one dose they previously were able to give, Dr. Russo explains.
The FDA specifically cited data from a 2015 clinical study of the JYNNEOS vaccine that evaluated the vaccine being given intradermally compared to subcutaneously. “The results of this study demonstrated that intradermal administration produced a similar immune response to subcutaneous administration, meaning individuals in both groups responded to vaccination in a similar way,” the FDA said in the press release.
“It requires more training and special needles to get at the right depth, but it causes a better immune response compared to the subcutaneous route, so less vaccine needs to be used,” says Jamie Alan, Ph.D., an associate professor of pharmacology and toxicology at Michigan State University. But, Alan said, it’s not “fully understood” why the vaccine may still be effective when it's given this way.
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