Successes in life sciences and international collaboration could be key to boosting the country’s high-quality output.
in which they described his new base-editing technique, which edits genomes by altering the composition of DNA“Issues with conventional CRISPR genome editing have been associated with its DNA cleavage process, which causes toxicity to cells or may result in unpredictable editing outcomes,” says Nishida.
For Japan to replicate these successes across other institutions and fields, however, and so sustain a reversal in its Nature Index performance, will require a concerted effort from policymakers. Recently established agencies are also trying to make a difference. Hayashi attributes the small improvement seen in Japan’s life-sciences research to the creation of the Japan Agency for Medical Research and Development , a national funding body overseen by the government. Founded in 2015 under former prime minister Shinzo Abe, the agency aims to rapidly progress medical research findings into treatments.
Regulators are still monitoring data about lecanemab’s safety after three deaths among patients in the study raised concerns about potentially dangerous side effects. Nonetheless, it’s the first drug of its kind to stem mental decline in a robust clinical trial, and has sparked great expectations.Japan still faces other persistent issues, however, that could be stymieing its progress.
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