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About one-third of Americans get only five to six hours of sleep every night instead of the recommended seven to eight hours.
Adequate vs. Poor Sleep. The researchers traced the absence of the antioxidant response in sleep-deprived cells to a cellular factor, NRF2, that becomes trapped in the cytoplasm. When damaging oxidants accumulate in cells, NRF2 usually moves into the nucleus to turn on the antioxidant response. After chronic sleep restriction the Cullin3 protein holds NRF2 in the cytoplasm.
“But that’s not how people act night after night. Most people get up around the same time each day but tend to delay their bedtime one to two hours,” Jelic says. “We wanted to copy that behavior, which is the most common sleep pattern we see in adults.”The women slept according to their usual routine; they went to bed 1.5 hours later than expected for the other six weeks. Each participant’s sleep was checked with wrist-worn sleep trackers.
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