A member of an important class of ion channel proteins can transiently rearrange itself into a larger structure with dramatically altered properties, according to a new study. The discovery is a significant advance in cell biology, likely solves a long-standing mystery about an unusual feature of some ion channels and has implications for the development of drugs targeting these proteins and for drug delivery.
A member of an important class of ion channel proteins can transiently rearrange itself into a larger structure with dramatically altered properties, according to a study led by researchers at Weill Cornell Medicine. The discovery is a significant advance in cell biology, likely solves a long-standing mystery about an unusual feature of some ion channels and has implications for the development of drugs targeting these proteins and for drug delivery.
The study's first author was Dr. Shifra Lansky, a postdoctoral research associate in the Scheuring lab in the Department of Anesthesiology. The work was performed in collaboration with Dr. Crina Nimigean's lab in the Department of Anesthesiology at Weill Cornell Medicine. "If you bite on a strong chili pepper, for example, your mouth will be insensitive and in pain for a few minutes, during which you won't want to take another bite," Dr. Scheuring said."Maybe that kind of protective alteration of sensitivity is what ion channel pore dilation is for."
Thus, they concluded, pore dilation is related to this transient pentameric state of ion channels that are normally tetramers.
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Study finds how some ion channels form structures permitting drug deliveryA member of an important class of ion channel proteins can transiently rearrange itself into a larger structure with dramatically altered properties, according to a study led by researchers at Weill Cornell Medicine. The discovery is a significant advance in cell biology, likely solves a long-standing mystery about an unusual feature of some ion channels and has implications for the development of drugs targeting these proteins and for drug delivery.
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