Genomics has come to form a framework for biology in the way that the periodic table forms one for chemistry. It touches everything
So the project is now truly over. But the captains and the kings departed long ago. Dr Watson and Dr Lander are both in the doghouse. In 2007, and again in 2019, the former made some appalling public remarks about genetics, intelligence and black people, and is pretty much shunned as a result. The latter’s robust approach to management—which did so much to get the project back on track in the face of Dr Venter’s challenge—is now out of sympathy with the times.
Making “transcriptomes”, of which this was an early example, has indeed become a useful tool. But the way. Genes themselves contain sequences called exons that end up in the messenger and others, called introns, that don’t.
And one other thing. The model of multi-centre collaboration pioneered by the International Human Genome Sequencing Consortium is now a standard way of doing biology. There is still a tension between the sort of diversity the consortium began with and the centralising economies-of-scale approach that Dr Lander imposed at the end.
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