A new study shows that genetic & non-genetic factors contribute to autistic traits, calling for a realignment of the concepts of genomics to incorporate the biosocial complexity of autism News & Views from kristienhens, Luca Chiapperino UAntwerpen unil
Rolland et al. found that rare loss-of-function variants previously associated with autism are also present in the general population and that these variants are associated with a decrease in IQ scores and income among the carriers — what the authors call ‘sub-diagnostic effects’. Of note, the authors offer a complex and multifactorial explanation of the contribution of these LoF variants in the various populations of reference .
However, the authors carefully postulate that there are unknown social–biological processes that make some people with a genetic predisposition to autism resilient to the manifestation of the condition. Therefore, specific social environments might act together with biological predispositions to produce both risk and resilience. Given the sensitivity of genetic findings related to IQ and autism, the authors should be commended for their careful interpretation and presentation of their results.
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