Intravenous immunoglobulin in combination with other therapeutics may be an effective treatment for patients with severe COVID-19, reports a study published in VirologyJ.
]. However, the mechanism of IVIg therapy is still uncertain, and its effectiveness in treating patients who are critically ill with severe COVID-19 is uncertain.
We hypothesized that there should be some cross-reactive antibody responses to epitopes that are shared by the four common coronaviruses that are currently in circulation and SARS-CoV-2. Thus, we examined this hypothesis by identification pre-existing Igs against conserved peptide sequences from the Spike and membrane proteins of SARS-CoV-2 in a healthy population.
An additional 197 healthy volunteers were recruited from the First Affiliated Hospital of Zhejiang University School of Medicine at the same time. These healthy volunteers were more than 20 years old, in good health, had no history of blood transfusion or monoclonal antibody therapy, and were free of infection by SARS-CoV-2 and the virus specific Igs .
This study was approved by the Ethics Committee of Taizhou Central Hospital and the First Affiliated Hospital, Zhejiang University School of Medicine.Polyprotein sequences of the structural proteins of coronaviruses responsible for the common cold and SARS-CoV-2 were obtained from the NCBI database . These protein sequences of the coronaviruses were performed with Vector NTI to find the evolutionally conserved amino acid residues.
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