The first line of defense in our immune systems are white blood cells, 40% to 70% of which are neutrophils. These cells rush to sites of injury or infection, producing proteins to promote inflammation and attack invading microbes. At the time of response, the proteins are decorated with carbohydrate molecules—called glycoproteins—yet scientists do not know when or how these complex molecules appear.
Now, however, an international research team may be a step closer to understanding when and how neutrophils arm their microbe-killing proteins. The finding, the researchers said, may have implications for refining personalized immune responses.
Neutrophils circulate in the blood in a resting state, with what researchers call an"arsenal of prepackaged cytosolic granules," which are subcellular compartments adorned with anti-microbial glycoproteins. These subcellular compartments are mobilized under specific environmental cues, allowing the neutrophils to move to where they are needed and react as needed for that specific threat.
According to researchers, their analysis indicated that a well-timed and coordinated expression of a specific type of glycoprotein early in the neutrophil's maturation was responsible for their restricted subcellular origin. The specific glycoprotein expression was coordinated with the initial development of the organelle that deploys a microbicidal response.
Deutschland Neuesten Nachrichten, Deutschland Schlagzeilen
Similar News:Sie können auch ähnliche Nachrichten wie diese lesen, die wir aus anderen Nachrichtenquellen gesammelt haben.
MISSING: 70-year-old man last seen near downtown HoustonGilbert Liandro was last seen Wednesday in the 700 block of N San Jacinto Street. He was wearing a white shirt, black pants and red/white shoes, police said.
Weiterlesen »
Silver Alert issued for missing 70-year-old New Braunfels manA Silver Alert has been issued for a missing 70-year-old New Braunfels man.
Weiterlesen »
New Braunfels Police searching for 70-year-old man, issued Silver AlertRuben Camareno was last seen around 12:30 p.m. on Saturday at 821 S Business 35 in New Braunfels.
Weiterlesen »
I-70’s Peña Boulevard exit closed for crash, fuel spillThe Peña Boulevard exit on eastbound Interstate 70 is closed after a two-vehicle crash caused a diesel fuel spill.
Weiterlesen »
NB ramp to Peña Boulevard from EB I-70 closed Monday due to crashThe northbound ramp to Peña Boulevard from eastbound Interstate 70 is expected to be closed until 8 a.m. Monday due to a crash, the Aurora Police Department tweeted.
Weiterlesen »
Here's Why 'Riverdale' Star Charles Melton Gained 40 Pounds For 'May December''I didn't know him from Riverdale. His looks were almost a deterrent.'
Weiterlesen »