A groundbreaking study conducted at the lab of Beth Stevens, PhD, at Boston Children's Hospital has revealed that an immune protein impacts neuronal protein synthesis in the aging brain.
Boston Children 's Hospital Jul 15 2024 A groundbreaking study conducted at the lab of Beth Stevens, PhD, at Boston Children 's Hospital has revealed that an immune protein impacts neuronal protein synthesis in the aging brain. Previous work from the Stevens lab had uncovered that immune cells in the central nervous system , microglia, help prune synapses in the developing brain by tagging synapses with the immune protein C1q.
Changes in brain protein production with age: In adult mice lacking a protein called C1q, there is a significant increase in the production of proteins in neurons and a change in the balance of proteins in the brain, suggesting that C1q may be important for keeping the brain's proteins in check. These changes are specific to age, with noticeable differences in protein production in adult mice compared to younger ones.
Impact on learning and memory: Deleting C1q in microglia in adult mice affects their ability to forget fear memories, showing C1q's importance in learning and memory. This suggests that C1q helps with memory and brain flexibility, potentially by interacting with specific neuronal complexes that impact neuronal protein production.
Protein Brain Cell Central Nervous System Children Hospital Laboratory Microglia Nervous System Neurons Protein Synthesis Research RNA Translation
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