Incorporating sampling weights into robust estimation of Cox proportional hazards regression model, with illustration in the Multi-Ethnic Study of Atherosclerosis - BMC Medical Research Methodology

COVID-19 vaccination linked to fewer cardiac events mountsinainyc

percentile, with sensitivity analyses performed using the 90percentile. Confidence intervals based on sandwich variance estimates were used throughout to account for the inverse-probability of sampling weights. Separate models were fitted for each of the immune cell traits, without adjustment for other traits. A conservative approach of Bonferroni correction [] was used to account for the 17 immune cell traits. Estimated hazard ratios are per SD of the percent of each immune cell type.

After correction for multiple testing, there were no significant associations between stroke and the immune cell traits . Given that there were only 70 stroke cases, the power to find an association was small, so the lack of clinically important conclusions is not surprising, but our focus is on the comparative results across methods.

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