Coordinated out of Uganda, the first-of-its-kind study is taking a double-pronged attack to HIV. Failure could mean no vaccine until at least the 2030s.
A novel trial that has been described as “the last roll of the dice” for a generation of HIV vaccines has entered its latter stages. Called PrEPVacc, the trial is testing two vaccines alongside two forms of pre-exposure prophylaxis to test vaccine efficacy while offering protection to prevent the spread of HIV. African-led and coordinated out of Entebbe, Uganda, with international support, its success could mark the start of a new phase of vaccine development.
estimates 630,000 people died from AIDS-related illness globally in 2022, while 39 million people are living with HIV, including 1.3 million people newly infected last year. The hope is that PrEPVacc will succeed where other trials have fallen short – most recently HVTN 702 , halted in February 2020, HVTN 705 , discontinued in 2021 and HVTN 706 in 2023, all of which were found to be safe but ineffective at preventing HIV.
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