The architecture of shattered genomes: Study demonstrates potential of new sequencing technologies NatureComms
, were computed as the fraction of the genomic feature with respect to the length of all chromosomes, excluding gaps of the reference genome in the computation.
Novel adjacencies with random connections: For the set of novel adjacencies from all cases, the connection between anchor points were permuted. Thus, the coordinates stayed the same, but the connection between breakpoints was altered. This permutation was used to evaluate A/B-compartment fusions and LAD/None-LAD fusions.
For case CT2, one chromosomal fragment was broken up manually in the reconstruction, because it led to the connection of chromosomal components, which were not compatible with the Hi-C grid . The position of the breakpoint was approximated from Hi-C alone.Manually curated large-scale novel adjacencies were used for the reconstruction of derivative chromosomes.
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Integration of High-Throughput Imaging and Multiparametric Metabolic Profiling Reveals a Mitochondrial Mechanism of Tenofovir ToxicityAbstract. Nephrotoxicity is a major cause of kidney disease and failure in drug development, but understanding of cellular mechanisms is limited, highlighting t
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Cross-sectional associations of different types of nature exposure with psychotropic, antihypertensive and asthma medicationBackground Exposure to natural environments is thought to be beneficial for human health, but the evidence is inconsistent. Objective To examine whether exposure to green and blue spaces in urban environments is associated with mental and physical health in Finland. Methods The Helsinki Capital Region Environmental Health Survey was conducted in 2015−2016 in Helsinki, Espoo and Vantaa in Finland (n=7321). Cross-sectional associations of the amounts of residential green and blue spaces within 1 km radius around the respondent’s home (based on the Urban Atlas 2012), green and blue views from home and green space visits with self-reported use of psychotropic (anxiolytics, hypnotics and antidepressants), antihypertensive and asthma medication were examined using logistic regression models. Indicators of health behaviour, traffic-related outdoor air pollution and noise and socioeconomic status (SES) were used as covariates, the last of these also as a potential effect modifier. Results Amounts of residential green and blue spaces or green and blue views from home were not associated with medications. However, the frequency of green space visits was associated with lower odds of using psychotropic medication (OR=0.67, 95% CI 0.55 to 0.82 for 3–4 times/week; 0.78, 0.63 to 0.96 for ≥5 times/week) and antihypertensive (0.64, 0.52 to 0.78; 0.59, 0.48 to 0.74, respectively) and asthma (0.74, 0.58 to 0.94; 0.76, 0.59 to 0.99, respectively) medication use. The observed associations were attenuated by body mass index, but no consistent interactions with SES indicators were observed. Conclusions Frequent green space visits, but not the amounts of residential green or blue spaces, or green and blue views from home, were associated with less frequent use of psychotropic, antihypertensive and asthma medication in urban environments. No data available based on General Data Protection Regulation.
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Preston Police thank Mother Nature as snowy footprints help ensnare suspectsFootprints in icy snow in Preston Pic: Tony Worrall The cold weather has done Preston Police a favour with a set of snowy footprints helping officers link t
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Footprints in snow help Preston police identify suspectsOfficers investigating an offence thank 'Mother Nature for her assistance' in catching two suspects.
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‘I Had My Son Outside Waitrose’: One Mum’s Story Of Her Surprise LabourWhen your baby wants out, it's not always where you planned. But, as this mum found, you can't argue with nature
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The beautiful woodland in Greater Manchester perfect for a winter walkKenworthy Woods is a haven for wildlife and has recently been named Manchester's newest nature reserve
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