Alzheimer's currently affects around one in nine US adults over the age of 65, and the disorder is expected to become even more prevalent in the future.
Current Alzheimer's treatments don't target this aspect of the disease, but it's possible there might be other avenues to mitigate the issue.
When researchers put the mice on a time-restricted feeding schedule, the animals showed noticeable improvements in memory function. Meanwhile,– long linked to Alzheimer's – were less likely to accumulate in the brains of the fasting mice. What's more, the mice on the feeding schedule followed a more regular sleeping pattern, were less hyperactive at night, and experienced"For many years, we assumed that the circadian disruptions seen in people with Alzheimer's are a result of neurodegeneration, but we're now learning it may be the other way around – circadian disruption may be one of the main drivers of Alzheimer's pathology,""This makes circadian disruptions a promising target for new...
The mice were only allowed to eat within a six-hour window each day. In humans, this would equate to fasting for 14 hours in every 24-hour cycle – and this seems to help to reset the naturalChanges were noticed right down to the molecular level too, with multiple genes related to disease andshowing differences in the way they were expressed in the Alzheimer's mice on a fasting schedule.
Adopting an intermittent fasting regime is something that people can do relatively easily, and relatively quickly – as treatments go, it's fairly straightforward. If the same results are found in human trials, it's another promising option to explore in the fight against
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