Intermittent fasting shows potential benefits for obesity treatment and brain-gut-microbiome health Brain Fasting Microbiome Obesity Gut Diurnal Rhythm Weightloss Nutrients_MDPI dgsomucla
Study: Brain–Gut–Microbiome Interactions and Intermittent Fasting in Obesity. Image Credit: Kreminska / Shutterstock
The Effect of Altered BGM Interactions on Obesity Significant levels of research have indicated the changes in bidirectional signaling within the BGM system in obese individuals. These changes are mediated by endocrine, metabolic, neural, and immune system-mediated mechanisms. This observation has been verified on specialized cells present in the gut, which are sensitive to many gut microbial metabolites, such as short-chain fatty acids .
The temporal dimension of food intake has only recently received widespread scientific attention. This food intake regulates the gut microbiome and aids in the bidirectional interaction between the brain and the gut. The marketing strategies of the US food industry have played a key role in creating and sustaining the unhealthy eating habits of the majority of the American population. Additionally, research has shown that portion sizes are directly related to food addiction and obesity.
Several obesity treatments, including different types of bariatric surgery, focus on altering how the upper gastrointestinal tract assimilates and processes food. Bariatric surgery is the only intervention that achieves robust long-term weight reduction, but it is invasive, costly, and has side effects.
Time-restricted Eating and Obesity TRE has gained significant recent attention, which combines 6-8 hours of mainly plant-based food intake daily and 16-18 hours of a ketogenic phase. As opposed to intermittent fasting, TRE does not require a reduction in caloric intake. The ketogenic phase allows the body to burn fat instead of drawing from a continuous glucose supply.
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