Booze initially slows activity in the amygdala, reducing feelings of anxiety, but rebound excitation in the amygdala the next day could cause 'hangxiety.'
August 6 marks International Hangover Day, and it's no coincidence that it arrives the day after International Beer Day.
"As soon as alcohol enters the brain, brain circuits begin to adjust to minimize the perturbations caused by alcohol and return circuits to baseline levels of functioning. As a result of this acute tolerance, when the alcohol wears off, activity in circuits that were suppressed by alcohol now overshoot baseline levels of activity," he added.
"Similarly, circuits initially activated by alcohol might be less active for a while when the alcohol wears off. While alcohol initially increases reward system activity in the brain, dampened reward activity could contribute to malaise and anhedonia during a hangover," Koob toldThere are many other ways alcohol can contribute to hangovers.
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