Interrupting treatment of patients on immune-suppressingmedicine doubles antibody response to COVID-19booster UniofNottingham LancetRespirMed
The Vaccine Response On Off Methotrexate trial, which will have implications for people on immune-suppressing medicines—who are among the millions of clinically vulnerable patients advised to"shield" during the pandemic—was carried out in collaboration with colleagues from the University of Manchester, Imperial College London, the University of Oxford and Queen Mary University London. The study was run by the Oxford Clinical Trials Research Unit .
The VROOM trial looked at the impact of interrupting methotrexate treatment for two weeks after a COVID-19 booster vaccination on vaccine responses in adults with autoimmune inflammatory conditions. The team compared the spike-antibody levels between the two groups four weeks and twelve weeks after they had received a COVID-19 vaccine dose. The spike-antibody blocks the virus from infecting cells inside the body.
The spike-antibody level reflects the strength of the antibody response. The research team are currently examining the quality of the antibody response by measuring its ability to kill live SARS-CoV-2 viruses and other variants of concern such as Omicron. "Implementing these results could vastly improve the protection provided by boosters against COVID-19 for millions of people living with these conditions. COVID-19 has left them vulnerable to serious illness, whilst still having to live with the painful and troubling effects of their conditions. We hope this evidence is the next step in helping them with their lives going forward."
"Thank you to all the participants who took part, we rely on their continued commitment to help us learn more and ultimately beat the virus."
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