Is constipation associated with hypertension and cardiovascular events in older Australian adults? SciReports FedUniAustralia constipation hypertension cardiovascular health wellbeing
By Dr. Chinta SidharthanJul 11 2023Reviewed by Danielle Ellis, B.Sc. In a recent study published in Scientific Reports, scientists investigated the association between constipation and cardiovascular events such as angina, myocardial infarction, transient ischemic attack, and stroke, as well as hypertension among a representative population of elderly hospitalized patients in Australia.
Constipation, common among the elderly, is believed to be linked to hypertension. While studies among the Japanese population and veterans in the United States have reported an association between constipation and an increased risk of ischemic stroke, coronary heart disease, and mortality due to stroke and other cardiovascular events, it remains unclear whether constipation is independently associated with cardiovascular events or hypertension.
The study examined cardiovascular events, including stroke, angina, transient ischemic attack, and myocardial infarction, which were diagnosed according to the tenth revision of the International Classification of Diseases. Results The results indicated that the multivariate-adjusted risk for cardiovascular events and hypertension was higher for patients with constipation as compared to those without constipation.
Based on growing evidence from research on the role of gut microbiomes in the pathophysiology of various diseases, the researchers believe that another mechanism through which constipation is linked to hypertension and cardiovascular disease is gut microbiome dysbiosis leading to inflammation and alterations in the production of short-chain fatty acids.
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