Researchers using the UK Biobank identified genetic markers linked to strict vegetarianism, revealing potential connections between vegetarianism, lipid metabolism, and brain activity. The study highlighted genes, particularly those active in the brain and related to cholesterol movement, as influential in an individual's inclination towards a vegetarian lifestyle.
By Vijay Kumar MalesuOct 9 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in PLoS ONE, researchers identified genetic loci associated with strict vegetarianism in United Kingdom Biobank participants using a genome-wide association study .
Despite its increasing popularity, only a tiny percentage of the global population practices strict vegetarianism. Interestingly, there appears to be a genetic aspect influencing dietary choices. Further research is needed to better understand how genetics may contribute to an individual's ability to adopt and maintain a vegetarian lifestyle.
UKB performed genotyping and quality control on its ethnically diverse participants using the UK Biobank Lung Exome Variant Evaluation and UK Biobank Axiom Array . Genotyped data were then pre-phased to determine individual haplotypes, followed by imputation using various reference panels. As a result, the imputed data consisted of over 93 million genetic markers.
The study used Scalable and Accurate Implementation of a GEneralized mixed model for genome-wide analysis, which considered factors like age and sex. Additional analyses utilized the Functional Mapping and Annotation platform . A gene-property analysis was executed to discern the specific tissues affected by the phenotype, highlighting the significance of 30 general tissue types. Several genes associated with vegetarianism were found to be particularly active in the brain. SNPs linked with vegetarianism were also associated with traits related to lipid metabolism and brain functioning.
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