The Psych-STRATA study seeks to identify biological and clinical markers that predict resistance to pharmacologic treatments, as well as those that predict response to possible alternative therapeutic options.
Having secured 11 million euros in funding from the European Union's Horizon Health program, a team of pharmacology, pharmacogenetics, and psychiatry experts has set to work in hopes of helping patients with severe mental illnesses. Their study, Psych-STRATA, seeks to identify biological and clinical markers that predict resistance to pharmacologic treatments, as well as those that predict response to possible alternative therapeutic options.
On this team is a group of researchers from the University of Cagliari, Cagliari, Sardinia, Italy. They are part of a network of international experts from 26 universities, research centers, and European associations, all of whom have vast experience in the fields of psychiatry, pharmacology, genetics, and statistics. Coordinating the project is Bernhard T. Baune, MD, PhD, MPH, a professor of psychiatry at the University of Münster, Münster, Germany.
The problem of drug resistance is of great relevance to psychiatrists. About one third of patients do not respond to pharmacologic therapies; as a result, their illness becomes more and more severe. This development has a major impact on these patients' quality of life. In addition, healthcare and social services face a rise in the costs associated with managing the illnesses.
In the University of Cagliari, Cagliari, Sardinia, Italy, group has two members from the Department of Biomedical Sciences — Alessio Squassina, PhD, head of the Pharmacogenetics Laboratory, and Claudia Pisanu, MD, PhD — and two translational clinical researchers from the Department of Medical Sciences and Public Health — Bernardo Carpiniello, MD, head of the Psychiatry Division, and Mirko Manchia, MD, PhD.
"The process of figuring out whether someone has drug resistance is complex," explained Squassina."It may require very long periods of treatment and observation which, in the end, severely impact the patient's chances of seeing a significant improvement in their symptoms and of being able to reintegrate themselves into society in the shortest possible timeframe.
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