Less Is More: The Diet Strategy Proven To Slow Aging in Healthy Adults

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Less Is More: The Diet Strategy Proven To Slow Aging in Healthy Adults
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Calorie restriction, a proven intervention to slow aging in animals, showed evidence of slowing the pace of biological aging in a human randomized trial. In a first-of-its-kind randomized controlled trial, an international team of researchers led by the Columbia Aging Center at Columbia Universit

Caloric restriction has been shown to slow aging in a groundbreaking study, with effects similar to smoking cessation interventions. The CALERIE™ trial found a 2-3% slowing in aging pace in healthy adults, suggesting that slowing human aging may be possible through interventions like intermittent fasting or time-restricted eating.

The CALERIE™ Phase-2 randomized controlled trial, funded by the U.S. National Institute on Aging, part of the National Institutes of Health, is the first-ever investigation of the effects of long-term calorie restriction in healthy, non-obese humans. The trial randomized 220 healthy men and women at three sites in the U. S. to a 25 percent calorie-restriction or normal diet for two years. CALERIE™ is an acronym for ‘Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy’.

“In contrast to the results for DunedinPace, there were no effects of intervention on other epigenetic clocks,” noted Calen Ryan, PhD, research scientist at Columbia’s Butler Aging Center and co-lead author of the study. “The difference in results suggests that dynamic ‘pace of aging’ measures like DunedinPACE may be more sensitive to the effects of intervention than measures of static biological age.

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