'Limoncella' apple polyphenol extract (LAPE) shows promise in reducing liver and intestinal inflammation in a mouse model of inflammatory bowel disease (IBD), highlighting potential natural treatment pathways
By Vijay Kumar MalesuMar 12 2024Reviewed by Susha Cheriyedath, M.Sc. In a recent study published in the International Journal of Molecular Sciences, a group of researchers evaluated the efficacy of 'Limoncella' apple polyphenol extract in mitigating inflammatory bowel disease -induced hepatotoxicity through its antioxidant and anti-inflammatory properties in a dinitro-benzenesulfonic acid -colitis mouse model.
About the study Chemicals like DNBS, myeloperoxidase , and other reagents were sourced from reputable suppliers, ensuring high purity for the study. For the investigation of LAPE, apples were harvested from Castelvetere del Calore, Italy, and processed using a method involving methanol to extract the polyphenols, which were then analyzed through high-performance liquid chromatography to identify the polyphenolic content.
Study results The present study analyzed the polyphenolic composition of LAPE using HPLC- Diode-Array Detection , revealing significant quantities of gallic acid, procyanidin B1, catechin, chlorogenic acid, and other polyphenols, indicating a rich polyphenolic profile beneficial for health. In experiments using the DNBS model of colitis in mice, LAPE showed promising anti-inflammatory properties by improving both macroscopic and histopathological damage caused by DNBS.
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