Long term high-fatdiet expands waistline and shrinks brain
s between AD, T2DM and obesity, and the underlying biochemical changes and mechanisms associated with metabolic disorders and AD tauopathy.HFD induced obesity of pR5 transgenic mice expressing P301L mutant human tau generates T2DM.pR5 mice are more vulnerable to HFD induced obesity compared to WT especially with increasing age.
pR5 mice are more vulnerable to HFD induced glucose intolerance impairment compared to WT especially with increasing age.Long term HFD aggravates tau hyperphosphorylation in pR5 transgenic mice.
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