People who take proton pump inhibitors for about 4½ years or more have a 33 percent higher risk of developing dementia, a new study shows. The researchers did not find a higher risk of dementia linked to shorter-term use.
Studies such as the recent observational study allow us “to have discussions, to be thoughtful about trying to dissect what might be contributing to this risk between a medicine and a cognitive outcome,” Day said. “It doesn’t mean we want all patients throwing these medications in the garbage.”
If you are using these medications for ulcers or gastrointestinal problems and stop using them, you could have potentially life-threatening consequences, Day said.People who have concerns about using prescription or over-the-counter PPIs should speak with their health-care providers before stopping these medications, experts say.
“If taking long term, patients should consult with a primary care physician or gastroenterologist to determine the diagnosis and treatment plan,” Fouad J. Moawad, spokesperson for the American Gastroenterological Association, said in a statement. Moawad also recommended lifestyle modifications, including reducing intake of foods known to trigger symptoms, not eating three hours before going to sleep, elevating the head of the bed and weight loss.
“For many patients, an on-demand approach to PPIs may work just fine and potentially carry less risk,” he wrote.
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