Low testosterone levels appear to protect kidney cells in mice from cell death. The finding could explain why women are at a lower risk of acute kidney injury than men
at Duke University in North Carolina collected kidney samples from eight mice – four females and four males – and genetically sequenced them. They identified 128 genes that were expressed differently between the two sexes and further analysis revealed many of these genes were related to a particular cell process called NRF2.
This suggests that testosterone reduces the NRF2 process in male mice, leaving them more susceptible to ferroptosis in their kidneys and potentially explaining why men have higher incidences of kidney injury, says Souma.
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