African countries with higher prevalence of malaria had a lower incidence of COVID-19, suggesting malaria might protect people against SARS-CoV-2 through the stimulation of innate immunity, finds a study in BMCInfectDis.
]. These epigenetic changes result in unfolding of chromatin regions that enhances transcription and gene expression of factors involved in the immune response. The changes are only partially removed after the primary stimulus is eliminated.
This sustained immunity would abolish the changes, if any, in the incidence of COVID-19—a single exposure to malaria could be enough to cause the trained immunity that would last for a couple of months. This would be more pronounced in regions endemic for malaria where people are constantly exposed to the parasite. Another limitation of the study would be the nature of the study design. No causal inference could be made from an ecological study. The design is just hypothesis-generating.
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