A study published in the journal Science Bulletin was led by Profs. Xiao-Long Zhou and En-Duo Wang (CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences).
N-extension of METTL8-Iso1 is critical in m3C32 biogenesis while METTL8-Iso4 is inactive in m3C32 modification activity due to absence of the N-extension. METTL8-Iso1 exhibited a relaxed tRNA substrate specificity to modify several cytoplasmic or even bacterial tRNAs. Credit: Science China Presswas led by Profs. Xiao-Long Zhou and En-Duo Wang .
tRNA is a key adaptor molecule in mRNA translation. There are a large number of post-transcriptional modifications on tRNA, which regulate the speed and fidelity of protein synthesis. 3-Methylcytosine modification is widely found at position 32 of the anticodon loops of several cytoplasmic and mitochondrial tRNAs in eukaryotes.
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