The findings demonstrated that the vaccine provided significant immune protection against all five strains of meningococcal bacteria.
“We are excited about the results of this study. We expect NmCV-5 to provide children and young adults with reliable protection against meningitis caused by meningococcal bacteria," said Dr. Ed Clarke, a pediatrician from the Vaccines and Immunity Theme at MRC Unit The Gambia at LSHTM and co-author of this study.
Meningitis epidemics have occurred in many parts of the world, according to the World Health Organization , but the disease most commonly affects 26 countries informing the meningitis belt. As per WHO, this disease claimed the lives of approximately 25,000 people in 2019. “Epidemic preparedness is the way forward in providing available, affordable, and accessible vaccines relevant to regions prone to meningitis outbreaks. Having meningitis vaccines should be a public health priority to prevent catastrophic outcomes during an outbreak and would be a game changer in the fight against meningitis,” said Dr.
The study is led by researchers from the Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine and researchers from Bamako in Mali.An effective, affordable, multivalent meningococcal conjugate vaccine is needed to prevent epidemic meningitis in the African meningitis belt. Data on the safety and immunogenicity of NmCV-5, a pentavalent vaccine targeting the A, C, W, Y, and X serogroups, have been limited.
Methods: We conducted a phase 3, noninferiority trial involving healthy 2-to-29-year-olds in Mali and Gambia. Participants were randomly assigned in a 2:1 ratio to receive a single intramuscular dose of NmCV-5 or the quadrivalent vaccine MenACWY-D. Immunogenicity was assessed at day 28. The noninferiority of NmCV-5 to MenACWY-D was assessed on the basis of the difference in the percentage of participants with a seroresponse or geometric mean titer ratios .
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