Nearly a quarter of patients who received Merck & Co's immunotherapy Keytru...
CHICAGO - Nearly a quarter of patients who received Merck & Co’s immunotherapy Keytruda as an initial treatment for advanced lung cancer were still alive after five years, according to data presented at a major medical meeting on Saturday.
“The uniformly negative outlook that has been associated with a diagnosis of advanced non-small cell lung cancer is certainly no longer appropriate,” said Dr. Edward Garon, a lung cancer specialist at the University of California, Los Angeles, who led the study. Keytruda, first approved for advanced melanoma in 2014, is Merck’s most important growth driver. It has overtaken Bristol’s Opdivo as the industry’s immuno-oncology leader with sales expected to top $10 billion this year and $20 billion in 2024, according to Refinitiv data.
Patients whose tumors had higher levels of the PD-L1 protein targeted by Keytruda fared best in the trial. In the previously untreated group, nearly 30 percent were alive after five years if their PD-L1 expression was 50 percent or greater, compared with a 15.7 percent 5-year survival with PD-L1 levels below 50 percent.Separately, researchers presented more details of a late stage study of Keytruda as an initial, or first-line, treatment for advanced gastric or gastroesophageal junction cancers.
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