Metformin reduces risk of long COVID by over 40% PostCOVID LongCOVID ChronicIllness Metformin Ivermectin Fluvoxamine ReduceRisk TheLancetInfDis
By Neha MathurJun 12 2023Reviewed by Benedette Cuffari, M.Sc. Long coronavirus disease 2019 is defined as the continuation or development of new COVID-19 symptoms three months after the initial infection with the severe acute respiratory syndrome coronavirus 2 . This highly heterogeneous disease can range from a single symptom to severe multi-organ involvement that can vary significantly in their duration. As a result, diagnosing and treating long COVID remains challenging.
About the study In the present study, researchers randomized all study participants to six groups that parallelly received metformin and ivermectin, metformin and fluvoxamine, metformin and placebo, ivermectin and placebo, fluvoxamine and placebo, or placebo and placebo. Here it is noteworthy that multiple factors influence the diagnosis of long COVID, such as access to care, willingness to seek it when experiencing post-COVID-19 symptoms, and awareness of long COVID in clinicians.
By Day 300, 93 study participants were diagnosed with long COVID. By this point, metformin treatment of patients with acute COVID-19 reduced the risk of long COVID by 41.3%, with a predicted aggregate incidence of 6.3% and 10.6% in the metformin and placebo groups, respectively. Conversely, the other two drugs, ivermectin and fluvoxamine, did not reduce the risk of long COVID in this trial.
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