Microbial “Dark Matter” Yields Gold – New Antibiotic Could Be a Powerful Weapon Against Superbugs

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Microbial “Dark Matter” Yields Gold – New Antibiotic Could Be a Powerful Weapon Against Superbugs
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A new powerful antibiotic, isolated from previously unstudied bacteria, shows promise in tackling harmful bacteria, including the multi-resistant 'superbugs'. Dubbed 'Clovibactin,' this antibiotic destroys bacteria in an unusual way, making it more difficult for bacteria to develop any resistance ag

of Boston , and the company NovoBiotic Pharmaceuticals now share the discovery of Clovibactin and its killing mechanism in the scientific journalAntimicrobial resistance is a major problem for human health and researchers worldwide are looking for new solutions. “We urgently need new antibiotics to combat bacteria that become increasingly resistant to most clinically used antibiotics,” says Dr. Markus Weingarth, a researcher from the Chemistry Department of Utrecht University.

“Clovibactin is different,” says Weingarth. “Since Clovibactin was isolated from bacteria that could not be grown before, pathogenic bacteria have not seen such an antibiotic before and had no time to develop resistance.” “Clovibactin wraps around the pyrophosphate like a tightly fitting glove. Like a cage that encloses its target” says Weingarth. This is what gives Clovibactin its name, which is derived from the Greek word “Klouvi”, which means cage. The remarkable aspect of Clovibactin’s mechanism is that it only binds to the immutable pyrophosphate that is common to cell wall precursors, but it ignores that variable sugar-peptide part of the targets.

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