Science, Space and Technology News 2023
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“Our data suggests that inhibiting the function of this particular enzyme, called 15-hydroxyprostaglandin dehydrogenase or 15-PGDH, with a small molecule boosted a naturally occurring compound in muscle tissues that help restore nerve connectivity, function, and strength,” said Wang.When skeletal muscles lose nerve function, a phenomenon called denervation, they atrophy and weaken.
“We wondered why this enzyme turns on with age if it has such a negative impact on muscle mass and strength,” said Wang. In studies of human tissues, the researchers detected aggregates of 15-PGDH in biopsies from a diverse range of human neuromuscular diseases, suggesting that inhibiting this enzyme could be beneficial.
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