Moderna begins next phase of Omicron-specific booster trial as study finds that antibodies remain durable despite 6-fold drop over 6 months

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Moderna begins next phase of Omicron-specific booster trial as study finds that antibodies remain durable despite 6-fold drop over 6 months
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Moderna has announced that the first participant has been dosed in the company's Phase 2 clinical trial of a coronavirus vaccine booster shot that is specific to the Omicron variant

Moderna announced Wednesday that the first participant has been dosed in the company's Phase 2 clinical trial of a coronavirus vaccine booster shot that is specific to the Omicron variant.

Moderna is advancing the trial into its next phase as research published Wednesday in the New England Journal of Medicine found that a booster dose of the vaccine remained durable against the Omicron variant but did show signs of waning antibody protection."We are reassured by the antibody persistence against Omicron at six months after the currently authorized 50 μg booster of mRNA-1273.

We've seen it before, Schaffner said, but we don't exactly know how this translates into real-world performance."It's not clear whether this translates into reduced protection particularly for severe disease," he said.Large population data shows that two doses of the vaccine plus a booster provides rigorous protection against severe disease, even against the Omicron variant.

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