Merkel cell carcinoma is a rare but highly aggressive form of skin cancer known for its rapid growth and tendency to metastasize. Despite the promise of immune checkpoint blockade therapy, which can boost the body's immune response against cancer cells, nearly half of patients do not respond to this treatment.
Moffitt Cancer CenterJul 26 2024 Merkel cell carcinoma is a rare but highly aggressive form of skin cancer known for its rapid growth and tendency to metastasize. Despite the promise of immune checkpoint blockade therapy, which can boost the body's immune response against cancer cells, nearly half of patients do not respond to this treatment.
The research team, co-led by Kenneth Tsai, M.D., Ph.D., vice chair of Pathology Research at Moffitt, and Jaehyuk Choi, M.D., Ph.D., at Northwestern University, discovered that those who respond to immune checkpoint blockade therapy have higher levels of preexisting tissue-resident CD8 T cells or Vδ1 γδ T cells within their tumors.
"Our findings not only highlight the potential to use specific genes and immune cells as biomarkers for predicting patient response to immune checkpoint blockade therapy, but also suggest several approaches for abrogating resistance and enhancing efficacy," Tsai said.
Cell Merkel Cell Carcinoma Cancer Efficacy Immune Response Immunotherapy Ph Research RNA RNA Sequencing Skin Skin Cancer Transcriptomics Tsai Tumor
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