Scientists elucidate how chemogenetic technology highjacks neuronal activity nature
) views of structural comparison of the receptors between hM3Dq-miniGq and hM4Di-miniGo complexes, respectively.or miniGq subunit in the structures of hM1R-G, Three views of the superposition of hM1R and hM3R structures. The CHS molecules in the hM1R or hM3R structure are shown in gray or yellow spheres, respectively., Side view of the binding pocket of the hM4Di-DCZ structure. Both DCZ and surrounding residues interacting with DCZ are shown in stick models.
The compound CNO is shown in both stick and sphere models and DCZ and surrounding residues are shown in the ball-and-stick model., Superposition of the binding pockets of hM3R-iperoxo, hM1R-iperoxo , and hM2R-iperoxo structures. The inset shows the structural comparison of the iperoxo molecules in the binding pockets of these three structures. Hydrogen bonds are indicated as dashed lines., Side view of the binding pockets of superposed hM3Dq-DCZ and hM3R-iperoxo structures.
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